Genetically predicted iron status was associated with the risk of prostate cancer.

ABSTRACT:

Introduction

Observational studies have reported a relationship between iron status and the risk of prostate cancer. However, it remains uncertain whether the association is causal or due to confounding or reverse causality. To further clarify the underlying causal relationship, we conducted a Mendelian randomization (MR) analysis.

Methods

We selected three genetic variants (rs1800562, rs1799945, and rs855791) closely correlated with four iron status biomarkers (serum iron, log-transformed ferritin, transferrin saturation, and transferrin) as instrumental variables. Summary statistics for prostate cancer were obtained from the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome consortium including 79,148 cases and 61,106 controls of

SUBMITTER: Ying J 

PROVIDER: S-EPMC9763611 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature