Simultaneous spectrofluorimetic determination of remdesivir and simeprevir in human plasma.

ABSTRACT: As new infectious mutations of SARS-CoV-2 emerged throughout the world, innovative therapies to counter the virus-altered drug sensitivities were urgently needed. Several antiviral options have been in clinical trials or in compassionate use for the treatment of SARS-CoV-2 infections in an attempt to minimize both clinical severity and viral shedding. Recent research indicated that simeprevir acts synergistically with remdesivir, allowing for a multiple-fold decrease in its effective dose when used at physiologically acceptable concentrations. The goal of this work is to develop a sensitive synchronous spectrofluorimetric approach to simultaneously quantify the two drugs in biological fluids. Using this method, remdesivir and simeprevir could be measured spectrofluorimetrically at 283 and

SUBMITTER: El Sharkasy ME 

PROVIDER: S-EPMC9763795 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature