Alveolar Biomarker Profiles in Subphenotypes of the Acute Respiratory Distress Syndrome.

ABSTRACT:

Objectives

We sought to determine whether hyperinflammatory acute respiratory distress syndrome (ARDS) and hypoinflammatory ARDS, which have been associated with differences in plasma biomarkers and mortality risk, also display differences in bronchoalveolar lavage (BALF) biomarker profiles. We then described the relationship between hyperinflammatory ARDS and hypoinflammatory ARDS to novel subphenotypes derived using BALF biomarkers.

Design

Secondary analysis of a randomized control trial testing omega-3 fatty acids for the treatment of ARDS.

Setting

Five North American intensive care units.

Patients

Adults (n = 88) on invasive mechanical ventilation within 48 hours of ARDS onset.

Interventions

None.

Measurements and main results

We classified 57

SUBMITTER: Sathe NA 

PROVIDER: S-EPMC9764239 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature