Higher systolic blood pressure is specifically associated with better islet beta-cell function in T2DM patients with high glycemic level.

ABSTRACT:

Background

Patients with type 2 diabetes mellitus (T2DM) usually have higher blood viscosity attributed to high blood glucose that can decrease blood supply to the pancreas. A mild increase in blood pressure (BP) has been reported as a potential compensatory response that can maintain blood perfusion in the islet. However, how BP influences beta-cell function in T2DM subjects remains inconsistent. This study aimed to examine the relationship between BP and beta-cell function in patients with T2DM under different HbA1c levels.

Methods

This is a cross-sectional study of 615 T2DM patients, whose clinical data were extracted from hospital medical records. Beta-cell function was assessed by insulin secretion-sensitivity index-2 (ISSI2). Multivariable linear regression analysis an

SUBMITTER: Xia Z 

PROVIDER: S-EPMC9764532 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature