Definition of a novel breast tumor-specific classifier based on secretome analysis.

ABSTRACT:

Background

During cancer development, the normal tissue microenvironment is shaped by tumorigenic events. Inflammatory mediators and immune cells play a key role during this process. However, which molecular features most specifically characterize the malignant tissue remains poorly explored.

Methods

Within our institutional tumor microenvironment global analysis (T-MEGA) program, we set a prospective cohort of 422 untreated breast cancer patients. We established a dedicated pipeline to generate supernatants from tumor and juxta-tumor tissue explants and quantify 55 soluble molecules using Luminex or MSD. Those analytes belonged to five molecular families: chemokines, cytokines, growth factors, metalloproteinases, and adipokines.

Results

When looking at tissue specifi

SUBMITTER: Sirven P 

PROVIDER: S-EPMC9764559 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature