Treatment outcomes and radiotherapy deintensification strategies in human papillomavirus-associated tonsil cancer.

ABSTRACT:

Background

Human papillomavirus (HPV)-positive tonsil cancer has a better prognosis than HPV-negative tonsil cancer. Deintensification strategies to reduce or avoid radiotherapy (RT) for patients with HPV-associated tonsil cancer have been suggested. This study investigated the treatment outcomes of patients with HPV-associated tonsil cancer and suggested RT deintensification strategies.

Methods

A cohort of 374 patients with HPV-associated tonsil cancer treated with primary surgery or RT between 2008 and 2020 was retrospectively evaluated. Survival and locoregional control rates after primary surgery or RT were analyzed, and propensity score matching was performed to adjust for clinical factors. Pearson's chi-square or Fisher's exact test was used to compare categorical vari

SUBMITTER: Lee J 

PROVIDER: S-EPMC9764715 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature