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ERG11 Analysis among Clinical Isolates of Trichosporon asahii with Different Azole Susceptibility Profiles.

ABSTRACT: We analyzed a cohort of Trichosporon asahii strains with different MICs of fluconazole and voriconazole and evaluated the presence of ERG11 mutations. ERG11 mutation conferring an amino acid change was found and its resistance potential was evaluated by cloning into Saccharomyces cerevisiae susceptible host strain. Transformants were not resistant to either fluconazole nor voriconazole. Our results suggest that ERG11 variants exist among T. asahii isolates, but are not responsible for resistance phenotypes.

SUBMITTER: Nobrega de Almeida J

PROVIDER: S-EPMC9765002 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

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ERG11 Analysis among Clinical Isolates of Trichosporon asahii with Different Azole Susceptibility Profiles.

Nobrega de Almeida João J Jimenez-Ortigosa Cristina C Francisco Elaine Cristina EC Colombo Arnaldo L AL Perlin David S DS

Antimicrobial agents and chemotherapy 20221114 12

We analyzed a cohort of Trichosporon asahii strains with different MICs of fluconazole and voriconazole and evaluated the presence of ERG11 mutations. ERG11 mutation conferring an amino acid change was found and its resistance potential was evaluated by cloning into Saccharomyces cerevisiae susceptible host strain. Transformants were not resistant to either fluconazole nor voriconazole. Our results suggest that ERG11 variants exist among T. asahii isolates, but are not respo ...[more]

PMID: 36374073

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