Natural Variation in Diauxic Shift between Patagonian Saccharomyces eubayanus Strains.

ABSTRACT: The study of natural variation can untap novel alleles with immense value for biotechnological applications. Saccharomyces eubayanus Patagonian isolates exhibit differences in the diauxic shift between glucose and maltose, representing a suitable model to study their natural genetic variation for novel strains for brewing. However, little is known about the genetic variants and chromatin regulators responsible for these differences. Here, we show how genome-wide chromatin accessibility and gene expression differences underlie distinct diauxic shift profiles in S. eubayanus. We identified two strains with a rapid diauxic shift between glucose and maltose (CL467.1 and CBS12357) and one strain with a remarkably low fermentation efficiency and longer lag phase during diauxic shift (QC18). This

SUBMITTER: Molinet J 

PROVIDER: S-EPMC9765239 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature