Host Cell Amplification of Nutritional Stress Contributes To Persistence in Chlamydia trachomatis.

ABSTRACT: Persistence, a viable but non-replicating growth state, has been implicated in diseases caused by Chlamydia trachomatis. Starvation of distinct nutrients produces a superficially similar persistent state, implying convergence on a common intracellular environment. We employed host-pathogen dual RNA-sequencing under both iron- and tryptophan-starved conditions to systematically characterize the persistent chlamydial transcriptome and to define common contributions of the host cell transcriptional stress response in shaping the intracellular environment. The transcriptome of the infected host cells was highly specific to each nutritional stress, despite comparable effects on chlamydial growth and development in each condition. In contrast, the chlamydial transcriptomes between nutritional co

SUBMITTER: Pokorzynski ND 

PROVIDER: S-EPMC9765610 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature