Effect of condylar chondrocyte exosomes on condylar cartilage osteogenesis in rats under tensile stress.

ABSTRACT: Background: Functional orthoses are commonly used to treat skeletal Class II malocclusion, but the specific mechanism through which they do this has been a challenging topic in orthodontics. In the present study, we aimed to explore the effect of tensile stress on the osteogenic differentiation of condylar chondrocytes from an exosomal perspective. Methods: We cultured rat condylar chondrocytes under resting and tensile stress conditions and subsequently extracted cellular exosomes from them. We then screened miRNAs that were differentially expressed between the two exosome extracts by high-throughput sequencing and performed bioinformatics analysis and osteogenesis-related target gene prediction using the TargetScan and miRanda softwares. Exosomes cultured under resting and

SUBMITTER: Shi Y 

PROVIDER: S-EPMC9766957 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature