Modeling the spatiotemporal spread of beneficial alleles using ancient genomes.

ABSTRACT: Ancient genome sequencing technologies now provide the opportunity to study natural selection in unprecedented detail. Rather than making inferences from indirect footprints left by selection in present-day genomes, we can directly observe whether a given allele was present or absent in a particular region of the world at almost any period of human history within the last 10,000 years. Methods for studying selection using ancient genomes often rely on partitioning individuals into discrete time periods or regions of the world. However, a complete understanding of natural selection requires more nuanced statistical methods which can explicitly model allele frequency changes in a continuum across space and time. Here we introduce a method for inferring the spread of a beneficial allele acros

SUBMITTER: Muktupavela RA 

PROVIDER: S-EPMC9767474 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature