Alteration of whole-brain amplitude of low-frequency fluctuation and degree centrality in patients with mild to moderate depression: A resting-state functional magnetic resonance imaging study.

ABSTRACT:

Background

Mild to moderate depressive disorder has a high risk of progressing to major depressive disorder.

Methods

Low-frequency amplitude and degree centrality were calculated to compare 49 patients with mild to moderate depression and 21 matched healthy controls. Correlation analysis was conducted to explore the correlation between the amplitude of low-frequency fluctuation (ALFF) and the degree centrality (DC) of altered brain region and the scores of clinical scale. Receiver operating characteristic (ROC) curves were further analyzed to evaluate the predictive value of above altered ALFF and DC areas as image markers for mild to moderate depression.

Results

Compared with healthy controls, patients with mild to moderate depression had lower ALFF values in the lef

SUBMITTER: Chen F 

PROVIDER: S-EPMC9768018 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature