The causal relationship between obesity and skin and soft tissue infections: A two-sample Mendelian randomization study.

ABSTRACT:

Objective

Many observational studies have shown that obesity strongly affects skin and soft tissue infections (SSTIs). However, whether a causal genetic relationship exists between obesity and SSTIs is unclear.

Methods

A two-sample Mendelian randomization (MR) study was used to explore whether obesity is causally associated with SSTIs using a publicly released genome-wide association study (GWAS). An inverse-variance weighted (IVW) analysis was used as the primary analysis, and the results are reported as the odds ratios (ORs). Heterogeneity was tested using Cochran's Q test and the I² statistic, and horizontal pleiotropy was tested using the MR-Egger intercept and MR pleiotropy residual sum and outlier (MR-PRESSO).

Results

The results of the MR analysis sh

SUBMITTER: Hu H 

PROVIDER: S-EPMC9768473 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature