Recent progress in drying technologies for improving the stability and delivery efficiency of biopharmaceuticals.

ABSTRACT:

Background

Most biopharmaceuticals are developed in liquid dosage forms that are less stable than solid forms. To ensure the stability of biopharmaceuticals, it is critical to use an effective drying technique in the presence of an appropriate stabilizing excipient. Various drying techniques are available for this purpose, such as freeze drying or lyophilization, spray drying, spray freeze-drying, supercritical fluid drying, particle replication in nonwetting templates, and fluidized bed drying.

Area covered

In this review, we discuss drying technologies and their applications in the production of stable solid-state biopharmaceuticals, providing examples of commercially available products or clinical trial formulations. Alongside this, we also review how different analytical

SUBMITTER: Emami F 

PROVIDER: S-EPMC9768793 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature