Characterization of glutamate carboxypeptidase 2 orthologs in trematodes.

ABSTRACT:

Background

Glutamate carboxypeptidase 2 (GCP2) belongs to the M28B metalloprotease subfamily encompassing a variety of zinc-dependent exopeptidases that can be found in many eukaryotes, including unicellular organisms. Limited information exists on the physiological functions of GCP2 orthologs in mammalian tissues outside of the brain and intestine, and such data are completely absent for non-mammalian species. Here, we investigate GCP2 orthologs found in trematodes, not only as putative instrumental molecules for defining their basal function(s) but also as drug targets.

Methods

Identified genes encoding M28B proteases Schistosoma mansoni and Fasciola hepatica genomes were analyzed and annotated. Homology modeling was used to create three-dimensional models of SmM28B and Fh

SUBMITTER: Jedlickova L 

PROVIDER: S-EPMC9768917 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature