NAA60 (HAT4): the newly discovered bi-functional Golgi member of the acetyltransferase family.

ABSTRACT: Chromatin structural organization, gene expression and proteostasis are intricately regulated in a wide range of biological processes, both physiological and pathological. Protein acetylation, a major post-translational modification, is tightly involved in interconnected biological networks, modulating the activation of gene transcription and protein action in cells. A very large number of studies describe the pivotal role of the so-called acetylome (accounting for more than 80% of the human proteome) in orchestrating different pathways in response to stimuli and triggering severe diseases, including cancer. NAA60/NatF (N-terminal acetyltransferase F), also named HAT4 (histone acetyltransferase type B protein 4), is a newly discovered acetyltransferase in humans modifying N-termini of tran

SUBMITTER: Donnarumma F 

PROVIDER: S-EPMC9769039 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature