Transient Polycomb activity represses developmental genes in growing oocytes.

ABSTRACT:

Background

Non-genetic disease inheritance and offspring phenotype are substantially influenced by germline epigenetic programming, including genomic imprinting. Loss of Polycomb Repressive Complex 2 (PRC2) function in oocytes causes non-genetically inherited effects on offspring, including embryonic growth restriction followed by post-natal offspring overgrowth. While PRC2-dependent non-canonical imprinting is likely to contribute, less is known about germline epigenetic programming of non-imprinted genes during oocyte growth. In addition, de novo germline mutations in genes encoding PRC2 lead to overgrowth syndromes in human patients, but the extent to which PRC2 activity is conserved in human oocytes is poorly understood.

Results

In this study, we identify a discrete peri

SUBMITTER: Jarred EG 

PROVIDER: S-EPMC9769065 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature