Tuning dynamic DNA- and peptide-driven self-assembly in DNA-peptide conjugates.

ABSTRACT: DNA-peptide conjugates offer an opportunity to marry the benefits of both biomolecular classes, combining the high level of programmability found with DNA, with the chemical diversity of peptides. These hybrid systems offer potential in fields such as therapeutics, nanotechnology, and robotics. Using the first DNA-β-turn peptide conjugate, we present three studies investigating the self-assembly of DNA-peptide conjugates over a period of 28 days. Time-course studies, such as these have not been previously conducted for DNA-peptide conjugates, although they are common in pure peptide assembly, for example in amyloid research. By using aging studies to assess the structures produced, we gain insights into the dynamic nature of these systems. The first study explores the influence varying amo

SUBMITTER: Taylor ER 

PROVIDER: S-EPMC9769108 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature