Essential Paralogous Proteins as Potential Antibiotic Multitargets in Escherichia coli.

ABSTRACT: Antimicrobial resistance threatens our current standards of care for the treatment and prevention of infectious disease. Antibiotics that have multiple targets have a lower propensity for the development of antibiotic resistance than those that have single targets and therefore represent an important tool in the fight against antimicrobial resistance. In this work, groups of essential paralogous proteins were identified in the important Gram-negative pathogen Escherichia coli that could represent novel targets for multitargeting antibiotics. These groups include targets from a broad range of essential macromolecular and biosynthetic pathways, including cell wall synthesis, membrane biogenesis, transcription, translation, DNA replication, fatty acid biosynthesis, and riboflavin and isopreno

SUBMITTER: Hardy CD 

PROVIDER: S-EPMC9769728 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature