Clinical SARS-CoV-2 Kinetic Profiles Are Dependent on the Viral Strain and Host Vaccination Status.

ABSTRACT: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection kinetics in a real-world, clinical setting represent a knowledge gap in understanding the underlying coronavirus disease 2019 (COVID-19) pathogenesis. There are scant reports of the dynamics describing the two principal components of the viral life cycle, namely, the rapid proliferation and slower clearance phases. Here, we present results from an ongoing workplace clinical surveillance study during which two vaccinated participants became infected with SARS-CoV-2 Omicron variant (BA.1. lineage). The subjects were followed longitudinally with high temporal resolution, allowing the kinetics of both viral phases to be characterized. The viral doubling times in the proliferation phase (3.3 to 3.5 h) and maximum measure

SUBMITTER: Gunawardana M 

PROVIDER: S-EPMC9769764 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature