In Silico Characterization of bla_NDM-Harboring Conjugative Plasmids in Acinetobacter Species.

ABSTRACT: New Delhi metallo-β-lactamase (NDM)-producing clinical strains in Acinetobacter spp. have been recently reported in many countries and have received considerable attention. The vast majority of bla_NDM cases occur on conjugative plasmids, which play a vital role in disseminating bla_NDM. To characterize the conjugative plasmids bearing bla_NDM genes in Acinetobacter spp., we analyzed the variants of bla_NDM, conjugative transfer regions, genetic contexts of bla_NDM, and the phylogenetic pattern of the 62 predicted bla_NDM-positive plasmids, which were selected from 1,191 plasmids of Acinetobacter species from GenBank. We identified 30 conjugative plasmids from the 62 bla_NDM

SUBMITTER: Tang B 

PROVIDER: S-EPMC9769834 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature