Emergence of an Extensive Drug Resistant Pseudomonas aeruginosa Strain of Chicken Origin Carrying bla_IMP-45, tet(X6), and tmexCD3-toprJ3 on an Inc_pRBL16 Plasmid.

ABSTRACT: This study reports an extensively drug resistant Pseudomonas aeruginosa strain PA166-2 which was of chicken origin and carrying bla_IMP-45, tet(X6) and tmexCD3-toprJ3 on a single plasmid. The strain was characterized by antimicrobial susceptibility testing, resistance gene screening, conjugation assay, whole-genome sequencing, and bioinformatics analysis. Strain PA166-2 was resistant to tigecycline and carbapenems. It belonged to ST313 and carried a plasmid pPA166-2-MDR, which belongs to the incompatibility group Inc_pRBL16. pPA166-2-MDR harbored a 78 Kb multidrug resistance (MDR) region carrying an array of antimicrobial resistance genes, including bla_IMP-45, tet(X6), and tmexCD3-toprJ3. The gene bla

SUBMITTER: Dong N 

PROVIDER: S-EPMC9769874 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature