Platelet Activation and Aggregation Induced by Streptococcus bovis/Streptococcus equinus Complex.

ABSTRACT: Streptococcus bovis/Streptococcus equinus complex (SBSEC) is a common cause of infective endocarditis (IE). For IE-pathogens, the capacity to activate and aggregate platelets is believed to be an important virulence mechanism. While the interactions between bacteria and platelets have been described in detail for many Gram-positive pathogens, little research has been carried out with SBSEC in this respect. Twenty-six isolates of the four most common species and subspecies of SBSEC identified in bacteremia were collected, and interactions with platelets were investigated in platelet rich plasma (PRP) from three donors. Aggregation was studied using light-transmission aggregometry and platelet activation using flow cytometry detecting surface upregulation of CD62P. Platelets and serum

SUBMITTER: Pernow G 

PROVIDER: S-EPMC9769897 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature