Circulating c-Met-Expressing Memory T Cells Define Cardiac Autoimmunity.

ABSTRACT:

Background

Autoimmunity is increasingly recognized as a key contributing factor in heart muscle diseases. The functional features of cardiac autoimmunity in humans remain undefined because of the challenge of studying immune responses in situ. We previously described a subset of c-mesenchymal epithelial transition factor (c-Met)-expressing (c-Met⁺) memory T lymphocytes that preferentially migrate to cardiac tissue in mice and humans.

Methods

In-depth phenotyping of peripheral blood T cells, including c-Met⁺ T cells, was undertaken in groups of patients with inflammatory and noninflammatory cardiomyopathies, patients with noncardiac autoimmunity, and healthy controls. Validation studies were carried out using human cardiac tissue and in an experimental m

SUBMITTER: Fanti S 

PROVIDER: S-EPMC9770129 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature