RBPMS2 Is a Myocardial-Enriched Splicing Regulator Required for Cardiac Function.

ABSTRACT:

Background

RBPs (RNA-binding proteins) perform indispensable functions in the post-transcriptional regulation of gene expression. Numerous RBPs have been implicated in cardiac development or physiology based on gene knockout studies and the identification of pathogenic RBP gene mutations in monogenic heart disorders. The discovery and characterization of additional RBPs performing indispensable functions in the heart will advance basic and translational cardiovascular research.

Methods

We performed a differential expression screen in zebrafish embryos to identify genes enriched in nkx2.5-positive cardiomyocytes or cardiopharyngeal progenitors compared to nkx2.5-negative cells from the same embryos. We investigated the myocardial-enriched gene RNA-binding protei

SUBMITTER: Akerberg AA 

PROVIDER: S-EPMC9770155 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature