Comprehensive analysis identifies as a critical prognostic prediction gene in breast cancer.

ABSTRACT:

Background

Aurora kinases (AURKs) family plays a vital role not only in cell division but also in tumorigenesis. However, there are still rare systematic analyses of the diverse expression patterns and prognostic value of the AURKs family in breast cancer (BC). Systematic bioinformatics analysis was conducted to explore the biological role, prognostic value, and immunologic function of AURKs family in BC.

Methods

The expression, prognostic value, and clinical functions of AURKs family in BC were evaluated with several bioinformatics web portals: ONCOMINE Gene Expression Profiling Interactive Analysis, Kaplan-Meier plotter, cBioPortal, Metascape, GeneMANIA, and LinkedOmics; and the result was verified using human tissues.

Results

The expression of AURKA and AURKB were

SUBMITTER: Hu T 

PROVIDER: S-EPMC9771277 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature