A novel intradermal tattoo-based injection device enhances the immunogenicity of plasmid DNA vaccines.

ABSTRACT: In recent years, tattooing technology has shown promising results toward evaluating vaccines in both animal models and humans. However, this technology has some limitations due to variability of experimental evaluations or operator procedures. The current study evaluated a device (intradermal oscillating needle array injection device: IONAID) capable of microinjecting a controlled dose of any aqueous vaccine into the intradermal space. IONAID-mediated administration of a DNA-based vaccine encoding the glycoprotein (GP) from the Ebola virus resulted in superior T- and B-cell responses with IONAID when compared to single intramuscular (IM) or intradermal (ID) injection in mice. Moreover, humoral immune responses, induced after IONAID vaccination, were significantly higher to those obtained w

SUBMITTER: Gomez AM 

PROVIDER: S-EPMC9771775 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature