Mild hypoxic-ischemic encephalopathy (HIE): timing and pattern of MRI brain injury.

ABSTRACT:

Background

Mild hypoxic-ischemic encephalopathy (HIE) is increasingly recognized as a risk factor for neonatal brain injury. We examined the timing and pattern of brain injury in mild HIE.

Methods

This retrospective cohort study includes infants with mild HIE treated at 9 hospitals. Neonatal brain MRIs were scored by 2 reviewers using a validated classification system, with discrepancies resolved by consensus. Severity and timing of MRI brain injury (i.e., acute, subacute, chronic) was scored on the subset of MRIs that were performed at or before 8 days of age.

Results

Of 142 infants with mild HIE, 87 (61%) had injury on MRI at median age 5 (IQR 4-6) days. Watershed (23%), deep gray (20%) and punctate white matter (18%) injury were most common. Among the 125 (88%) inf

SUBMITTER: Li Y 

PROVIDER: S-EPMC9771796 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature