Intrauterine inflammation exacerbates maladaptive remodeling of the immature myocardium after preterm birth in lambs.

ABSTRACT:

Background

Antenatal conditions that are linked with preterm birth, such as intrauterine inflammation, can influence fetal cardiac development thereby rendering the heart more vulnerable to the effects of prematurity. We aimed to investigate the effect of intrauterine inflammation, consequent to lipopolysaccharide exposure, on postnatal cardiac growth and maturation in preterm lambs.

Methods

Preterm lambs (~129 days gestational age) exposed antenatally to lipopolysaccharide or saline were managed according to contemporary neonatal care and studied at postnatal day 7. Age-matched fetal controls were studied at ~136 days gestational age. Cardiac tissue was sampled for molecular analyses and assessment of cardiac structure and cardiomyocyte maturation.

Results

Lambs deli

SUBMITTER: Vrselja A 

PROVIDER: S-EPMC9771797 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature