Assessment of asymmetric dimethylarginine and homocysteine in epileptic children receiving antiepileptic drugs.

ABSTRACT:

Background

Epilepsy is a neurological disease that requires long-term antiepileptic drugs (AEDs). The old generation of AEDs may affect serum homocysteine and asymmetric dimethylarginine (ADMA) and disturb lipid levels. The aim of the study was to evaluate serum ADMA, homocysteine, lipid profile, and carotid intima-media thickness (CIMT) in epileptic children.

Methods

This study was implemented on 159 epileptic children who were subdivided into 3 subgroups, with 53 receiving sodium valproate, 53 receiving levetiracetam, and 53 receiving polytherapy, for over 6 months and 53 healthy children.

Results

Low-density lipoprotein, triglycerides, and cholesterol levels were increased in epileptic children (p < 0.001), which were higher in those receiving multidrug followed by

SUBMITTER: Mahmoud AA 

PROVIDER: S-EPMC9771805 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature