Ovarian cancer mutational processes drive site-specific immune evasion.

ABSTRACT: High-grade serous ovarian cancer (HGSOC) is an archetypal cancer of genomic instability^1-4 patterned by distinct mutational processes^5,6, tumour heterogeneity^7-9 and intraperitoneal spread^7,8,10. Immunotherapies have had limited efficacy in HGSOC^11-13, highlighting an unmet need to assess how mutational processes and the anatomical sites of tumour foci determine the immunological states of the tumour microenvironment. Here we carried out an integrative analysis of whole-genome sequencing, single-cell RNA sequencing, digital histopathology and multiplexed immunofluorescence of 160 tumour sites from 42 treatment-naive patients with HGSOC. Homologous recombination-deficient HRD-Dup (BRCA1 mutant-like) and HRD-Del (BRCA2 mutant-like) tumou

SUBMITTER: Vazquez-Garcia I 

PROVIDER: S-EPMC9771812 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature