Clinical features, biochemistry, and HLA-DRB1 status in youth-onset type 1 diabetes in Mali.

ABSTRACT:

Objective

Limited information is available regarding youth-onset diabetes in Mali. We investigated demographic, clinical, biochemical, and genetic features in new diabetes cases in children and adolescents.

Research design and methods

The study was conducted at Hôpital du Mali in Bamako. A total of 132 recently-diagnosed cases <21 years were enrolled. Demographic characteristics, clinical information, biochemical parameters (blood glucose, HbA1c, C-peptide, glutamic acid decarboxylase-65 (GAD-65) and islet antigen-2 (IA2) autoantibodies) were assessed. DNA was genotyped for HLA-DRB1 using high-resolution genotyping technology.

Results

A total of 130 cases were clinically diagnosed as type 1 diabetes (T1D), one with type 2 diabetes (T2D), and one with secondary diabete

SUBMITTER: Besancon S 

PROVIDER: S-EPMC9771900 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature