Cortico-cortical evoked potentials in response to varying stimulation intensity improves seizure localization.

ABSTRACT:

Objective

As single pulse electrical stimulation (SPES) is increasingly utilized to help localize the seizure onset zone (SOZ), it is important to understand how stimulation intensity can affect the ability to use cortico-cortical evoked potentials (CCEPs) to delineate epileptogenic regions.

Methods

We studied 15 drug-resistant epilepsy patients undergoing intracranial EEG monitoring and SPES with titrations of stimulation intensity. The N1 amplitude and distribution of CCEPs elicited in the SOZ and non-seizure onset zone (nSOZ) were quantified at each intensity. The separability of the SOZ and nSOZ using N1 amplitudes was compared between models using responses to titrations, responses to one maximal intensity, or both.

Results

At 2 mA and above, the increase in N1 a

SUBMITTER: Hays MA 

PROVIDER: S-EPMC9771930 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature