Prescription opioids and longitudinal changes in cognitive function in older adults: A population-based observational study.

ABSTRACT:

Background

Opioids are frequently prescribed to alleviate pain in older adults, yet the relationships between prescription opioids and long-term cognitive function are unclear.

Methods

In this analysis of the Mayo Clinic Study of Aging, a longitudinal population-based cohort study of older adults with formal neuropsychological testing and cognitive evaluations performed every 15 months, the associations between prescription opioids, global and domain-specific cognitive function, and mild cognitive impairment were evaluated through time-dependent linear mixed effects and Cox proportional hazards models.

Results

Four thousand two hundred eighteen participants (51% male) were included with enrollment between 11/1/2004 and 4/1/2019 and median age of 76 (interquartile rang

SUBMITTER: Warner NS 

PROVIDER: S-EPMC9771934 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature