Neural resources shift under Methylphenidate: A computational approach to examine anxiety-cognition interplay.

ABSTRACT: The reciprocal interplay between anxiety and cognition is well documented. Anxiety negatively impacts cognition, while cognitive engagement can down-regulate anxiety. The brain mechanisms and dynamics underlying such interplay are not fully understood. To study this question, we experimentally and orthogonally manipulated anxiety (using a threat of shock paradigm) and cognition (using methylphenidate; MPH). The effects of these manipulations on the brain and behavior were evaluated in 50 healthy participants (25 MPH, 25 placebo), using an n-back working memory fMRI task (with low and high load conditions). Behaviorally, improved response accuracy was observed as a main effect of the drug across all conditions. We employed two approaches to understand the neural mechanisms underlying MPH-ba

SUBMITTER: Saggar M 

PROVIDER: S-EPMC9772074 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature