Comprehensive Molecular Characterization of Gallbladder Carcinoma and Potential Targets for Intervention.

ABSTRACT:

Purpose

Gallbladder carcinoma (GBC) is an uncommon and aggressive disease, which remains poorly defined at a molecular level. Here, we aimed to characterize the molecular landscape of GBC and identify markers with potential prognostic and therapeutic implications.

Experimental design

GBC samples were analyzed using the MSK-IMPACT (Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets) platform (targeted NGS assay that analyzes 505 cancer-associated genes). Variants with therapeutic implications were identified using OncoKB database. The associations between recurrent genetic alterations and clinicopathologic characteristics (Fisher exact tests) or overall survival (univariate Cox regression) were evaluated. P values were adjusted for multiple te

SUBMITTER: Giraldo NA 

PROVIDER: S-EPMC9772093 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature