Calcium activity is a degraded estimate of spikes.

ABSTRACT: Recording action potentials extracellularly during behavior has led to fundamental discoveries regarding neural function-hippocampal neurons respond to locations in space,¹ motor cortex neurons encode movement direction,² and dopamine neurons signal reward prediction errors³-observations undergirding current theories of cognition,⁴ movement,⁵ and learning.⁶ Recently it has become possible to measure calcium flux, an internal cellular signal related to spiking. The ability to image calcium flux in anatomically^7,8 or genetically⁹ identified neurons can extend our knowledge of neural circuit function by allowing activity to be monitored in specific cell types or projections, or in the

SUBMITTER: Hart EE 

PROVIDER: S-EPMC9772124 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature