Associations of cord blood leukocyte telomere length with adiposity growth from infancy to adolescence.

ABSTRACT:

Objective

Leukocyte telomere length (LTL) may be a biomarker for chronic disease susceptibility, but no work has tested this hypothesis directly. Our study investigated associations of LTL at birth with markers of adiposity growth that are linked with cardiometabolic health later in life.

Methods

Participants were 375 children in Project Viva (48% female, 71% White). Body mass index (BMI) trajectories from birth to 18 years were tracked using repeated measures of BMI collected in physical examinations and via medical records, then used to predict age (months) and magnitude (kg/m² ) of BMI peak and rebound. LTL was measured from cord blood via duplex quantitative PCR. A binary variable indicating LTL shorter than the reference population average was the primary exp

SUBMITTER: Qureshi F 

PROVIDER: S-EPMC9772131 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature