An Advanced Thermal Decomposition Method to Produce Magnetic Nanoparticles with Ultrahigh Heating Efficiency for Systemic Magnetic Hyperthermia.

ABSTRACT: Due to the limited heating efficiency of available magnetic nanoparticles, it is difficult to achieve therapeutic temperatures above 44 °C in relatively inaccessible tumors during magnetic hyperthermia following systemic administration of nanoparticles at clinical dosage (≤10 mg kg^-1 ). To address this, a method for the preparation of magnetic nanoparticles with ultrahigh heating capacity in the presence of an alternating magnetic field (AMF) is presented. The low nitrogen flow rate of 10 mL min^-1 during the thermal decomposition reaction results in cobalt-doped nanoparticles with a magnetite (Fe₃ O₄ ) core and a maghemite (γ-Fe₂ O₃ ) shell that exhibit the highest intrinsic loss power reported to date of 47.5 nH m²

SUBMITTER: Demessie AA 

PROVIDER: S-EPMC9772135 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature