Poly(ADP-ribosyl)ating enzymes cooperate to coordinate development.

ABSTRACT: The transcriptome is subject to rapid and massive changes during the transition between developmental stages. These changes require tight control to avoid the undesired reactivation of gene expression that is only important for previous developmental stages and, if unchecked during transition between developmental stages, could lead to anarchic proliferation and formation of malignant tumors. In this context, the involvement of chromatin factors is important since they can directly regulate the expression of multiple genes at the same time. Poly(ADP-ribose) enzymes, involved in several processes from DNA repair to transcription regulation, might play a role in this regulation. Here, we report that PARP-1 and PARG cooperate to temporally regulate the gene expression profile during the larva

SUBMITTER: Bordet G 

PROVIDER: S-EPMC9772176 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature