Relevance of prediction scores derived from the SARS-CoV-2 first wave, in the evolving UK COVID-19 second wave, for safe early discharge and mortality: a PREDICT COVID-19 UK prospective observational cohort study.

ABSTRACT:

Objective

Prospectively validate prognostication scores, SOARS and 4C Mortality Score, derived from the COVID-19 first wave, for mortality and safe early discharge in the evolving pandemic with SARS-CoV-2 variants (B.1.1.7 replacing D614) and healthcare responses altering patient demographic and mortality.

Design

Protocol-based prospective observational cohort study.

Setting

Single site PREDICT and multisite ISARIC (International Severe Acute Respiratory and Emerging Infections Consortium) cohorts in UK COVID-19 second wave, October 2020 to January 2021.

Participants

1383 PREDICT and 20 595 ISARIC SARS-CoV-2 patients.

Primary outcome measures

Relevance of SOARS and 4C Mortality Score determining in-hospital mortality and safe early discharge in the evolv

SUBMITTER: Ghani H 

PROVIDER: S-EPMC9772190 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature