Lysophosphatidic acid signaling via LPA₆ : A negative modulator of developmental oligodendrocyte maturation.

ABSTRACT: The developmental process of central nervous system (CNS) myelin sheath formation is characterized by well-coordinated cellular activities ultimately ensuring rapid and synchronized neural communication. During this process, myelinating CNS cells, namely oligodendrocytes (OLGs), undergo distinct steps of differentiation, whereby the progression of earlier maturation stages of OLGs represents a critical step toward the timely establishment of myelinated axonal circuits. Given the complexity of functional integration, it is not surprising that OLG maturation is controlled by a yet fully to be defined set of both negative and positive modulators. In this context, we provide here first evidence for a role of lysophosphatidic acid (LPA) signaling via the G protein-coupled receptor LPA₆

SUBMITTER: Spencer SA 

PROVIDER: S-EPMC9772207 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature