Global metabolic profiles in a non-human primate model of maternal immune activation: implications for neurodevelopmental disorders.

ABSTRACT: Epidemiological evidence implicates severe maternal infections as risk factors for neurodevelopmental disorders, such as ASD and schizophrenia. Accordingly, animal models mimicking infection during pregnancy, including the maternal immune activation (MIA) model, result in offspring with neurobiological, behavioral, and metabolic phenotypes relevant to human neurodevelopmental disorders. Most of these studies have been performed in rodents. We sought to better understand the molecular signatures characterizing the MIA model in an organism more closely related to humans, rhesus monkeys (Macaca mulatta), by evaluating changes in global metabolic profiles in MIA-exposed offspring. Herein, we present the global metabolome in six peripheral tissues (plasma, cerebrospinal fluid, three regions of

SUBMITTER: Boktor JC 

PROVIDER: S-EPMC9772216 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature