Ideal current dipoles are appropriate source representations for simulating neurons for intracranial recordings.

ABSTRACT:

Objective

To determine whether dipoles are an appropriate simplified representation of neural sources for stereo-EEG (sEEG).

Methods

We compared the distributions of voltages generated by a dipole, biophysically realistic cortical neuron models, and extended regions of cortex to determine how well a dipole represented neural sources at different spatial scales and at electrode to neuron distances relevant for sEEG. We also quantified errors introduced by the dipole approximation of neural sources in sEEG source localization using standardized low-resolution electrotomography (sLORETA).

Results

For pyramidal neurons, the coefficient of correlation between voltages generated by a dipole and neuron model were > 0.9 for distances > 1 mm. For small regions of cortex (∼0.1 

SUBMITTER: Thio BJ 

PROVIDER: S-EPMC9772254 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature