Uncovering the antimalarial potential of toad venoms through a bioassay-guided fractionation process.

ABSTRACT: Malaria remains to date one of the most devastating parasitic diseases worldwide. The fight against this disease is rendered more difficult by the emergence and spread of drug-resistant strains. The need for new therapeutic candidates is now greater than ever. In this study, we investigated the antiplasmodial potential of toad venoms. The wide array of bioactive compounds present in Bufonidae venoms has allowed researchers to consider many potential therapeutic applications, especially for cancers and infectious diseases. We focused on small molecules, namely bufadienolides, found in the venom of Rhinella marina (L.). The developed bio-guided fractionation process includes a four solvent-system extraction followed by fractionation using flash chromatography. Sub-fractions were obtained thr

SUBMITTER: Wells M 

PROVIDER: S-EPMC9772263 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature