Intra- and inter-operator variability in MRI-based manual segmentation of HCC lesions and its impact on dosimetry.

ABSTRACT:

Purpose

The aim was to quantify inter- and intra-observer variability in manually delineated hepatocellular carcinoma (HCC) lesion contours and the resulting impact on radioembolization (RE) dosimetry.

Methods

Ten patients with HCC lesions treated with Y-90 RE and imaged with post-therapy Y-90 PET/CT were selected for retrospective analysis. Three radiologists contoured 20 lesions manually on baseline multiphase contrast-enhanced MRIs, and two of the radiologists re-contoured at two additional sessions. Contours were transferred to co-registered PET/CT-based Y-90 dose maps. Volume-dependent recovery coefficients were applied for partial volume correction (PVC) when reporting mean absorbed dose. To understand how uncertainty varies with tumor size, we fit power models regress

SUBMITTER: Covert EC 

PROVIDER: S-EPMC9772368 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature