Development and validation of MRI-based model for the preoperative prediction of macrotrabecular hepatocellular carcinoma subtype.

ABSTRACT:

Background

Macrotrabecular hepatocellular carcinoma (MTHCC) has a poor prognosis and is difficult to diagnose preoperatively. The purpose is to build and validate MRI-based models to predict the MTHCC subtype.

Methods

Two hundred eight patients with confirmed HCC were enrolled. Three models (model 1: clinicoradiologic model; model 2: fusion radiomics signature; model 3: combined model 1 and model 2) were built based on their clinical data and MR images to predict MTHCC in training and validation cohorts. The performance of the models was assessed using the area under the curve (AUC). The clinical utility of the models was estimated by decision curve analysis (DCA). A nomogram was constructed, and its calibration was evaluated.

Results

Model 1 is easier to build than m

SUBMITTER: Bilal Masokano I 

PROVIDER: S-EPMC9772375 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature