Recurrent RNA edits in human preimplantation potentially enhance maternal mRNA clearance.

ABSTRACT: Posttranscriptional modification plays an important role in key embryonic processes. Adenosine-to-inosine RNA editing, a common example of such modifications, is widespread in human adult tissues and has various functional impacts and clinical consequences. However, whether it persists in a consistent pattern in most human embryos, and whether it supports embryonic development, are poorly understood. To address this problem, we compiled the largest human embryonic editome from 2,071 transcriptomes and identified thousands of recurrent embryonic edits (>=50% chances of occurring in a given stage) for each early developmental stage. We found that these recurrent edits prefer exons consistently across stages, tend to target genes related to DNA replication, and undergo organized loss in abnor

SUBMITTER: Ding Y 

PROVIDER: S-EPMC9772385 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature