Establishment and validation of a redox-related long non-coding RNAs prognostic signature in head and neck squamous cell carcinoma.

ABSTRACT: Reduction and oxidation (redox) reactions occur in living organisms as part of normal cellular metabolism. Here, we established a novel redox-related long non-coding RNAs (rrlncRNAs) signature to predict the prognosis and therapeutic response in Head and neck squamous cell carcinoma (HNSCC). The expression profile and clinical information were obtained from the TCGA project. In total, 10 differently expressed rrlncRNAs associated with prognosis were identified and involved in a prognostic risk score signature by the least absolute shrinkage and selection operator penalized Cox analysis. The area under the receiver operating characteristic curves of the survival rates predicted by the rrlncRNAs signature over one, two, and three years were found to be 0.651, 0.670, and 0.679. Following the

SUBMITTER: Liu K 

PROVIDER: S-EPMC9772388 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature