Prevotella genus and its related NOD-like receptor signaling pathway in young males with stage III periodontitis.

ABSTRACT:

Background

As periodontitis progresses, the oral microbiota community changes dynamically. In this study, we evaluated the dominant bacteria and their roles in the potential pathway in young males with stage III periodontitis.

Methods

16S rRNA sequencing was performed to evaluate variations in the composition of oral bacteria between males with stage I and III periodontitis and identify the dominant bacteria of each group. Function prediction was obtained based on 16S rRNA sequencing data. The inhibitor of the predominant pathway for stage III periodontitis was used to investigate the role of the dominant bacteria in periodontitis in vivo and in vitro.

Results

Chao1 index, Observed Species and Phylogenetic Diversity (PD) whole tree values were significan

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC9772451 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature